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Book Recommendations?

Discussion in 'Electrical Engineering' started by Matthew Crema, Dec 3, 2003.

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  1. Hello,

    Can anyone recommend a good book on electric circuits for neurophysiology?

    I have seen circuits called "voltage clamps" and "current clamps" that I
    would like to understand in more detail.

    I have a strong background in general intrumentation, and I'd like some
    material that deals with the particular issues involved in making
    neuronal recordings in vivo. Specifically, I need to design a circuit
    that can be used interchangeably for both micro-stimulation AND
    recording of neuronal activity.

    Thank You.
  2. Hi,

    Thanks for your response. You are correct in saying that an electrode
    is stuck into the creature's brain (in this case a Long-Evans rat, we
    have IACUC approval). These electrods are small enough (and well
    sheilded) so that we can actually stick them into individual cells and
    record the activity of these single cells.

    Much research has been done involving the "recording" of neuronal
    activity. Less has been done with "microstimulation" (ie inducing the
    neurons to fire by injecting pulses of current). I have done a fairly
    extensive literature search of articles like these.

    The catch here is that we want a circuit that will selectively stimulate
    or record from the same electrode without having to remove it.
    Furthermore, we want to have 64 or 128 of these cricuits operating on
    individual neurons at the same time. We also want to mount the circuit
    board on the rat's head, and yet it needs to be lightweight enough to
    not affect the rat's behavior.

    I have found very few circuits that have been designed for this kind of
    function. One promising one that I found in a yet unpublished paper
    (found on a website) looks like this:

    | C2 |
    C1 | |
    Neuron -----||-----Opamp---------To Computer
    Stimulation --FET
    Control Signal---


    (Assuming the formatting is right) It looks to me like they are using
    the opamp (with negative feedback and inverting input to GND) to record
    the neuron's activity. They are able to stimulate the same neuron by
    turning on the transistor switch with a control signal.

    I'd like to find a few more papers like this, but it looks like it
    hasn't been done much, so I thought I'd take a step back and try to find
    a book on general circuits/electrophysiology.

    Thanks again.
  3. I just read that over and I meant "non-inverting input is tied to GND"
    where I typed "inverting input is tied to GND".

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